于彬

其他情况简介：

       于彬，教授，硕士生导师。willhill官方网站生物医学大数据研究团队负责人，人工智能与生物医学大数据研究中心主任。2005年6月硕士毕业于上海大学计算数学专业，中国科学技术大学在职博士，加拿大University of Calgary访问学者。目前主要从事可解释人工智能、机器学习、数据挖掘、生物医学图像处理、生物信息学、计算生物学与系统生物学的研究。教育部学科评估专家，教育部学位中心评审专家。山东省生物信息学会秘书长。中国计算机学会生物信息学专业委员会执行委员，中国计算机学会人工智能与模式识别专业委员会委员，中国计算机学会大数据专业委员会委员，中国自动化学会智能健康与生物信息专业委员会委员，中国细胞生物学学会功能基因组信息学与系统生物学分会理事。国际期刊Frontiers in Bioinformatics副主编。IEEE BIBM (生物医学与生物信息学) 程序委员会委员。近年来主持国家自然科学基金面上项目 (1项)、山东省重点研发计划项目 (1项)、山东省自然科学基金面上项目 (3项)、教育部产学合作协同育人项目 (1项)、山东省高等学校科技计划项目 (2项)、山东省重点实验室开放基金 (1项)、海南省重点实验室开放基金 (1项)、青岛海尔集团研发项目 (2项)。承担国家自然科学基金项目 (2项)、国家社会科学基金项目 (1项)、山东省自然科学基金项目 (5项)、山东省优秀中青年科学家科研奖励基金计划项目 (1项)、山东省高等学校科技计划项目 (3项)、青岛市科技计划基础研究项目 (2项) 等科研项目26项。2012、2014、2017年三次获山东省高校科研成果二等奖，2008、2009、2016年三次获山东省高校科研成果三等奖。近年来在相关研究领域的主要期刊发表学术论文120余篇，参编著作两部。其中100余篇作为第一作者或通讯作者发表在SCI (包括中科院1区、2区多篇TOP期刊)、EI检索刊物上。SCI总他引数2503，H-index 29，高被引论文5篇。多篇论文被哈佛大学、剑桥大学、康奈尔大学、密歇根大学、加州大学、伊利诺伊大学香槟分校、大阪大学、新加坡南洋理工大学、蒙纳士大学、新南威尔士大学、美国国立卫生研究院、欧洲分子生物学实验室、德国人工智能研究中心等世界著名高校科研机构引用。多次受邀担任Cell、PNAS、IEEE Transactions on Cybernetics、Information Fusion、Bioinformatics、Briefings in Bioinformatics、Knowledge-Based Systems、Expert Systems With Applications、PLOS Computational Biology、Genomics, Proteomics & Bioinformatics、Applied Soft Computing、IEEE Journal of Biomedical and Health Informatics、BMC Genomics、International Journal of Biological Sciences、Journal of Proteome Research、IEEE/ACM Transactions on Computational Biology and Bioinformatics、Engineering Applications of Artificial Intelligence、Artificial Intelligence Review、iScience、Neural Computing and Applications、Computers in Biology and Medicine、Journal of Chemical Information and Modeling、Biomedical Signal Processing and Control、Journal of Chemical Information and Modeling、MATCH Communications in Mathematical and in Computer Chemistry、Chemometrics and Intelligent Laboratory Systems、Journal of Biomedical Informatics、Methods、BMC Microbiology、BMC Bioinformatics、Soft Computing、Biotechnology Journal、Molecular Genetics and Genomics、Mathematical Biosciences、Neural Processing Letters等SCI期刊审稿人。

      近年来获校教学研究一、二等奖9项。指导研究生获得山东省优秀硕士学位论文，山东省优秀成果奖，willhill官方网站第十届研究生“学术之星”，校优秀硕士毕业论文。指导本科生参加国家大学生创新计划项目1项及中国科学院大学生创新计划项目3项。指导本科生毕业论文4次获得山东省优秀学士学位论文，10次获得校级优秀毕业论文。

       团队与美国俄亥俄州立大学、加拿大卡尔加里大学、沙特阿卜杜拉国王科技大学、中国科学技术大学、中山大学、山东大学、中南大学等著名高校建立了密切的合作关系。欢迎同学们积极报考计算机科学与技术、软件工程、计算机技术专业研究生，加入我们团队。同时也欢迎对人工智能、机器学习、图像处理与大数据挖掘方向感兴趣的全校各专业大二、大三、大四本科生加入我们团队。

[1]国家自然科学基金面上项目，62172248，2022/01/-2025/12，在研，主持

[2]山东省重点研发计划项目，2019GGX101001，2019/01-2020/12，已结题，主持

[3]山东省自然科学基金面上项目，ZR2021MF098，2022/01-2024/12，在研，主持

[4]山东省自然科学基金面上项目，ZR2018MC007，2018/03-2021/06，已结题，主持

[5]山东省自然科学基金面上项目，ZR2013AM007，2013/10-2016/10，已结题，主持

[6]2018年教育部第一批产学合作协同育人项目 (浪潮集团)，201801023017，2018/10-2019/10，已结题，主持

[7]山东省高等学校科技计划项目，J17KA159，2017/06-2019/12，已结题，主持

[8]山东省高等学校科技计划项目，J13LI54，2013/01-2015/12，已结题，主持

[9]海南省计算科学与应用重点实验室开放课题，JSKX202001，2021/01-2023/12，在研，主持

[10]山东省智慧矿山信息技术重点实验室开放课题，2017/10-2018/09，已结题，主持

[1]山东高等学校优秀科研成果奖自然科学类，二等奖， 2014

[2]山东高等学校科学技术奖本科科学技术类，三等奖，2016

[3]山东高等学校科学技术奖本科科学技术类，二等奖，2017

[4]山东高等学校优秀科研成果奖自然科学类，二等奖，2012

[5]山东高等学校优秀科研成果奖自然科学类，三等奖，2009

[6]山东高等学校优秀科研成果奖自然科学类，三等奖，2008

[7]山东省优秀硕士学位论文指导老师，2020

[8]山东省研究生优秀成果奖三等奖指导老师，2019

[9]山东省优秀学位论文指导老师，2017

[10]山东省优秀学位论文指导老师，2015

[11]山东省优秀学位论文指导教师，2010

[12]山东省优秀学位论文指导教师，2009

[1]Yifei Wang#, Xue Wang#, Cheng Chen, Hongli Gao, Adil Salhi, Xin Gao, Bin Yu*. RPI-CapsuleGAN: Predicting RNA-protein interactions through an interpretable generative adversarial capsule network. Pattern Recognition, 2023, 141: 109626. (JCR 1区 TOP IF=8.518 CCF B)

[2]Pengju Ding, Yifei Wang, Xinyu Zhang, Xin Gao, Guozhu Liu, Bin Yu*. DeepSTF: predicting transcription factor binding sites by interpretable deep neural networks combining sequence and shape. Briefings in Bioinformatics, 2023, 24(4): bbad231. (JCR 1区 TOP IF=13.994 CCF B)

[3] Mingxiang Zhang, Hongli Gao, Xin Liao, Baoxing Ning, Haiming Gu*, Bin Yu*. DBGRU-SE: Predicting drug-drug interactions based on double BiGRU and squeeze-and-excitation attention mechanism. Briefings in Bioinformatics, 24(4): bbad184. (JCR 1区 TOP IF=13.994 CCF B)

[4]Hongli Gao#, Bin Zhang#, Long Liu, Shan Li, Xin Gao*, Bin Yu*. A universal framework for single-cell multi-omics data integration with graph convolutional networks. Briefings in Bioinformatics, 2023, 24(3): bbad081. (JCR 1区TOP IF=13.994 CCF B)

[5]Yutong Yu, Pengju Ding, Hongli Gao, Guozhu Liu, Fa Zhang*, Bin Yu*. Cooperation of local features and global representations by a dual-branch network for transcription factor binding sites prediction. Briefings in Bioinformatics, 2023, 24(2): bbad036. (JCR 1区 TOP IF=13.994 CCF B)

[6]Xiaolin Wang#, Hongli Gao#, Ren Qi, Ruiqing Zheng, Xin Gao*, Bin Yu*. scBKAP: a clustering model for single-cell RNA-Seq data based on bisecting K-means. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2023, 20(3): 2007- 2015. (JCR 1区 IF=3.702 CCF B)

[7]Hongli Gao#, Cheng Chen#, Shuangyi Li, Congjing Wang, Weifeng Zhou, Bin Yu*. Prediction of protein-protein interactions based on ensemble residual convolutional neural network. Computers in Biology and Medicine, 2023, 152: 106471. (JCR 1区 IF=6.698)

[8]Tingting Zhang, Jihua Jia, Cheng Chen, Yaqun Zhang*, Bin Yu*. BiGRUD-SA: Protein S-sulfenylation sites prediction based on BiGRU and self-attention. Computers in Biology and Medicine, 2023, 163: 107145. (SCI, 1区 IF=6.698)

[9]Minghui Wang, Lu Yan, Jihua Jia, Jiali Lai, Hongyan Zhou*, Bin Yu*. DE-MHAIPs: Identification of SARS-CoV-2 phosphorylation sites based on differential evolution multi-feature learning and multi-head attention mechanism. Computers in Biology and Medicine, 2023, 160: 106935. (JCR 1区 IF=6.698)

[10]Yuan Cao, Weifeng Zhou, Min Zang, Dianlong An, Yan Feng*, Bin Yu*. MBANet: A 3D convolutional neural network with multi-branch attention for brain tumor segmentation from MRI images. Biomedical Signal Processing and Control, 2023, 80: 104296. (JCR 1区 IF=5.076)

[11]Yushuang Liu, Shuping Jin, Hongli Gao, Xue Wang, Congjing Wang, Weifeng Zhou, Bin Yu*. Predicting the multi-label protein subcellular localization through multi-information fusion and MLSI dimensionality reduction based on MLFE classifier. Bioinformatics, 2022, 38(5): 1223-1230 (JCR 1区 TOP IF=6.931 CCF B)

[12]Qinqin Wei#, Qingmei Zhang#, Hongli Gao, Tao Song, Adil Salhi, Bin Yu*. DEEPStack-RBP: Accurate identification of RNA-binding proteins based on autoencoder feature selection and deep stacking ensemble classifier. Knowledge-Based Systems, 2022, 256: 109875. (JCR 1区 TOP IF=8.139 CCF C)

[13]Minghui Wang#, Lili Song#, Yaqun Zhang, Hongli Gao, Lu Yan, Bin Yu*. Malsite-Deep：Prediction of protein malonylation sites through deep learning and multi-information fusion based on NearMiss-2 strategy. Knowledge-Based Systems, 2022, 240: 108191 (JCR 1区 TOP IF=8.139 CCF C)

[14]Bin Yu*, Xue Wang, Yaqun Zhang, Hongli Gao, Yifei Wang, Yushuang Liu, Xin Gao*. RPI-MDLStack: Predicting RNA-protein interactions through deep learning with stacking strategy and LASSO. Applied Soft Computing, 2022, 120: 108676 (JCR 1区 TOP IF=8.263)

[15]Bin Yu*, Yaqun Zhang, Xue Wang, Hongli Gao, Jianqiang Sun, Xin Gao*. Identification of DNA modification sites based on elastic net and bidirectional gated recurrent unit with convolutional neural network. Biomedical Signal Processing and Control, 2022, 75: 103566 (JCR 1区 IF=5.076)

[16]Yaqun Zhang#, Zhaomin Yu#, Bin Yu*, Xue Wang, Hongli Gao, Jianqiang Sun, Shuangyi Li. StackRAM: a cross-species method for identifying RNA N6-methyladenosine sites based on stacked ensemble. Chemometrics and Intelligent Laboratory Systems, 2022, 222: 104495 (JCR 1区 IF=4.175)

[17]Yan Zhang, Zhiwen Jiang, Cheng Chen, Qinqin Wei, Haiming Gu, Bin Yu*. DeepStack-DTIs: Predicting Drug-target Interactions Using LightGBM Feature Selection and Deep Stacked Ensemble Classifier. Interdisciplinary Sciences-Computational Life Sciences, 2022, 14(2):311-330. (JCR 2区 IF=3.492)

[18]Wankun Chen#, Weifeng Zhou#, Ling Zhu, Yuan Cao, Haiming Gu*, Bin Yu*. MTDCNet: A 3D multi-threading dilate convolutional network for brain tumor automatic segmentation. Journal of Biomedical Informatics, 2022, 133: 104173. (JCR 1区 IF=8.000 CCF C)

[19]Qi Zhang#, Yandan Zhang#, Shan Li, Yu Han, Shuping Jin, Haiming Gu, Bin Yu*. Accurate prediction of multi-label protein subcellular localization through multi-view feature learning with RBRL classifier. Briefings in Bioinformatics, 2021, 22(5): bbab012. (JCR 1区 TOP IF=11.622 CCF B)

[20]Bin Yu*, Chen Chen, Ren Qi, Ruiqing Zheng, Patrick J. Lawrence, Xiaolin Wang, Anjun Ma, Haiming Gu. scGMAI: a Gaussian mixture model for clustering single-cell RNA-seq data based on deep autoencoder. Briefings in Bioinformatics, 2021, 22(4): bbaa316. (JCR 1区 TOP IF=11.622 CCF B)

[21]Bin Yu#,*, Cheng Chen#, Xiaolin Wang, Zhaomin Yu, Anjun Ma, Bingqiang Liu. Prediction of protein-protein interactions based on elastic net and deep forest. Expert Systems with Applications, 2021, 176: 114876. (JCR 1区 TOP IF=6.954 CCF C)

[22]Qingmei Zhang#, Peishun Liu#, Xue Wang, Yaqun Zhang, Yu Han, Bin Yu*. StackPDB: Predicting DNA-binding proteins based on XGB-RFE feature optimization and stacking ensemble classifier. Applied Soft Computing, 2021, 99: 106921. (JCR 1区 TOP IF=6.725)

[23]Yan Zhang #, Yao Lu#, Wankun Chen, Yankang Chang, Haiming Gu, Bin Yu*. MSMANet: A multi-scale mesh aggregation network for brain tumor segmentation. Applied Soft Computing, 2021, 110: 107733. (JCR 1区 TOP IF=6.725)

[24]Cheng Chen#, Han Shi#, Zhiwen Jiang, Adil Salhi, Ruixin Chen, Xuefeng Cui, Bin Yu*. DNN-DTIs: Improved drug-target interactions prediction using XGBoost feature selection and deep neural network. Computers in Biology and Medicine, 2021, 136: 104676. (JCR 1区 IF=4.589)

[25]Xue Wang#, Yaqun Zhang#, Bin Yu*, Adil Salhi, Ruixin Chen, Lin Wang, Zengfeng Liu. Prediction of protein-protein interaction sites through eXtreme gradient boosting with kernel principal component analysis. Computers in Biology and Medicine, 2021, 134: 104516. (JCR 1区 IF=4.589)

[26]Minghui Wang#, Lingling Yue#, Xinhua Yang, Xiaolin Wang, Yu Han, Bin Yu*. Fertility-LightGBM: A fertility-related protein prediction model by multi-information fusion and light gradient boosting machine. Biomedical Signal Processing and Control, 2021, 68: 102630. (JCR 1区 IF=3.880)

[27]Qi Zhang#, Shan Li#, Qingmei Zhang, Yandan Zhang, Yu Han, Ruixin Chen, Bin Yu*. MpsLDA-ProSVM: Predicting multi-label protein subcellular localization by wMLDAe dimensionality reduction and ProSVM classifier. Chemometrics and Intelligent Laboratory Systems, 2021, 208: 104216. (JCR 1区 IF=3.491)

[28]Yushuang Liu#, Shuping Jin#, Lili Song#, Yu Han, Bin Yu*. Prediction of protein ubiquitination sites via multi-view features based on eXtreme gradient boosting classifier. Journal of Molecular Graphics & Modelling, 2021, 107: 107962. (JCR 2区 IF=2.518)

[29]Zhaoqian Liu, Jingtong Feng, Bin Yu, Qin Ma*, Bingqiang Liu*. The functional determinants in the organization of bacterial genomes. Briefings in Bioinformatics, 2021, 22(3): bbaa172. (JCR 1区 TOP IF=11.622)

[30]Bin Yu*, Wenying Qiu, Cheng Chen, Anjun Ma, Jing Jiang, Hongyan Zhou, Qin Ma*. SubMito-XGBoost: predicting protein submitochondrial localization by fusing multiple feature information and eXtreme gradient boosting. Bioinformatics, 2020, 36(4): 1074-1081. (JCR 1 区 TOP IF=6.937 CCF B)

[31]Bin Yu*, Cheng Chen, Hongyan Zhou, Bingqiang Liu, Qin Ma*. GTB-PPI: predict protein–protein interactions based on L1-regularized logistic regression and gradient tree boosting. Genomics, Proteomics & Bioinformatics, 2020, 18(5): 582-592. (JCR 1区 TOP IF=7.691)

[32]Cheng Chen#, Qingmei Zhang#, Bin Yu#,*, Zhaomin Yu, Patrick J. Lawrence, Qin Ma, Yan Zhang. Improving protein-protein interactions prediction accuracy using XGBoost feature selection and stacked ensemble classifier. Computers in Biology and Medicine, 2020, 123: 103899. (JCR 1 区 IF=3.434)

[33]Minghui Wang, Xiaowen Cui, Bin Yu*, Cheng Chen, Qin Ma, Hongyan Zhou. SulSite-GTB: identification of protein S-sulfenylation sites by fusing multiple feature information and gradient tree boosting. Neural Computing & Applications, 2020, 32(17): 13843-13862. (JCR 1 区 IF=4.774 CCF C)

[34]Bin Yu#,*, Zhaomin Yu#, Anjun Ma, Cheng Chen, Bingqiang Liu, Baoguang Tian, Qin Ma. DNNAce: Prediction of prokaryote lysine acetylation sites through deep neural networks with multi-information fusion. Chemometrics and Intelligent Laboratory Systems, 2020, 200: 103999. (JCR 1 区 IF=2.895)

[35]Minghui Wang#, Xiaowen Cui#, Shan Li, Xinhua Yang, Anjun Ma, Yusen Zhang, Bin Yu*. DeepMal: accurate prediction of protein malonylation sites by deep neural networks. Chemometrics and Intelligent Laboratory Systems, 2020, 207: 104175. (JCR 1 区 IF=2.895)

[36]Qi Zhang#, Shan Li#, Bin Yu*, Qingmei Zhang, Yu Han, Yan Zhang, Qin Ma. DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier. Chemometrics and Intelligent Laboratory Systems, 2020, 206: 104148. (JCR 1 区 IF=2.895)

[37]Xiaomeng Sun#, Tingyu Jin#, Cheng Chen#, Xiaowen Cui, Qin Ma, Bin Yu*. RBPro-RF: Use Chou's 5-steps rule to predict RNA-binding proteins via random forest with elastic net. Chemometrics and Intelligent Laboratory Systems, 2020, 197: 103919. (JCR 1 区 IF=2.895)

[38]Yaning Liu#, Zhaomin Yu#, Cheng Chen, Yu Han, Bin Yu*. Prediction of protein crotonylation sites through LightGBM classifier based on SMOTE and elastic net. Analytical Biochemistry, 2020, 609(15): 113903. (JCR 1 区 IF=2.877)

[39]Yanhao Huo#, Lihui Xin#, Chuanze Kang, Minghui Wang, Qin Ma, Bin Yu*. SGL-SVM: A novel method for tumor classification via support vector machine with sparse group Lasso. Journal of Theoretical Biology, 2020, 486: 110098. (JCR 1 区IF=2.327)

[40]Minghui Wang, Lingling Yue, Xiaowen Cui, Cheng Chen, Hongyan Zhou, Qin Ma, Bin Yu*. Prediction of Extracellular Matrix Proteins by Fusing Multiple Feature Information, Elastic Net, and Random Forest Algorithm. Mathematics, 2020, 8(2): 169. (JCR 2 区 IF=1.747)

[41]Xiaoying Wang#, Bin Yu#,*, Anjun Ma, Cheng Chen, Bingqiang Liu, Qin Ma*. Protein-protein interaction sites prediction by ensemble random forests with synthetic minority oversampling technique. Bioinformatics, 2019, 35(14): 2395-2402. (JCR 1 区 TOP IF=5.610 CCF B)

[42]Han Shi#, Simin Liu#, Junqi Chen#, Xuan Li, Qin Ma, Bin Yu*. Predicting drug-target interactions using Lasso with random forest based on evolutionary information and chemical structure. Genomics, 2019, 111(6): 1839-1852. (JCR 1 区IF=6.205)

[43]Jianying Lin, Hui Chen, Shan Li, Yushuang Liu, Xuan Li, Bin Yu*. Accurate prediction of potential druggable proteins based on genetic algorithm and Bagging-SVM ensemble classifier. Artificial Intelligence In Medicine, 2019, 98: 35-47. (JCR 1 区 IF=4.383 CCF C)

[44]Cheng Chen#, Qingmei Zhang#, Qin Ma, Bin Yu*. LightGBM-PPI: predicting protein-protein interactions through LightGBM with multi-information fusion. Chemometrics and Intelligent Laboratory Systems, 2019, 191: 54-64. (JCR 1 区IF=2.895)

[45]Chuanze Kang, Yanhao Huo, Lihui Xin, Baoguang Tian, Bin Yu*. Feature selection and tumor classification for microarray data using relaxed Lasso and generalized multi-class support vector machine. Journal of Theoretical Biology, 2019, 463: 77-91. (JCR 1 区 IF=2.327)

[46]Xiaowen Cui#, Zhaomin Yu#, Bin Yu#,*, Minghui Wang, Baoguang Tian, Qin Ma. UbiSitePred: a novel method for improving the accuracy of ubiquitination sites prediction by using LASSO to select the optimal Chou's pseudo components. Chemometrics and Intelligent Laboratory Systems, 2019, 184:  28-43. (JCR 1 区IF=2.895)

[47]Hongyan Zhou, Cheng Chen, Minghui Wang, Qin Ma, Bin Yu*. Predicting Golgi-resident protein types using conditional covariance minimization with XGBoost based on multiple features fusion. IEEE Access, 2019, 7(1): 144154-144164. (JCR 1 区 IF=3.745)

[48]Baoguang Tian, Xue Wu, Cheng Chen, Wenying Qiu, Qin Ma, Bin Yu*. Predicting protein-protein interactions by fusing various Chou's pseudo components and using wavelet denoising approach. Journal of Theoretical Biology, 2019, 462: 329-346. (JCR 1 区 IF=2.327)

[49]Bin Yu#,*, Shan Li#, Wenying Qiu, Minghui Wang, Junwei Du, Yusen Zhang, Xing Chen. Prediction of subcellular location of apoptosis proteins by incorporating PsePSSM and DCCA coefficient based on LFDA dimensionality reduction. BMC Genomics, 2018, 19: 478. (JCR 1 区 TOP IF=3.501)

[50]Wenying Qiu#, Shan Li#, Xiaowen Cui, Zhaomin Yu, Minghui Wang, Junwei Du, Yanjun Peng*, Bin Yu*. Predicting protein submitochondrial locations by incorporating the pseudo-position specific scoring matrix into the general Chou's pseudo-amino acid composition. Journal of Theoretical Biology, 2018, 450: 86-103. (JCR 1 区 IF=2.701)

[1]基于深度森林的蛋白质-蛋白质相互作用预测方法.中国，ZL202010021475.4，第1完成人

[2]基于信息融合和深度学习的原核生物乙酰化位点预测方法.中国，ZL201911363577.8，第1完成人

[3]基于stacking集成的RNA中N6-甲基腺苷修饰位点预测方法.中国，ZL202010021486.2，第1完成人

[1]研究生课程，生物计算，32学时

[2]本科生课程，数据科学导论，32学时